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| c. 1500 |
| | | The first modern lock gates are installed on a canal in Milan, probably designed by Leonardo da Vinci | |
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| c. 1500 |
| | | The Inca empire has about 25,000 miles of well-serviced roads, designed for caravans of llamas | |
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| c. 1520 |
| | | Europe's new printing presses make possible the first pamphlet war, spreading instant arguments for and against the Reformation | |
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| 1530 |
| | | German botanist Otto Brunfels publishes Living images of plants, the first serious work of natural history with printed illustrations | |
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| c. 1550 |
| | | The tinderbox provides a new way of making fire - with just flint, steel and tinder | |
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| 1560 |
| | | A book to teach good handwriting is published by Gianfrancesco Cresci, with examples engraved on copper plates | |
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| 1569 |
| | | Flemish cartographer Gerardus Mercator publishes a map of the world, using the projection now known by his name | |
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| 1589 |
| | | An English clergyman, William Lee, develops the world's first industrial machinery, to knit stockings | |
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| 1590 |
| | | Zacharias Janssen, a spectacle maker in the Dutch town of Middelburg, creates the first microscope | |
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| 1595 |
| | | A year after Mercator's death, his son publishes a bound collection of his maps with the title Atlas, or Cosmographic Meditations | |
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